Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism

Human mesenchymal stem cells (hMSCs) are being increasingly pursued as potential therapies for immune-mediated conditions, including multiple sclerosis. Although they can suppress human Th1 responses, they reportedly can reciprocally enhance human Th17 responses. Here, we investigated the mechanisms...

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Bibliographic Details
Published in:Stem Cells Transl Med
Main Authors: Rozenberg, Ayal, Rezk, Ayman, Boivin, Marie-Noëlle, Darlington, Peter J., Nyirenda, Mukanthu, Li, Rui, Jalili, Farzaneh, Winer, Raz, Artsy, Elinor A., Uccelli, Antonio, Reese, Jane S., Planchon, Sarah M., Cohen, Jeffrey A., Bar-Or, Amit
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2016
Subjects:
Cell-Based Drug Development, Screening, and Toxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070498/
https://ncbi.nlm.nih.gov/pubmed/27400792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0243
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