Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCF(Skp2)

Smad4/DPC4, a common signal transducer in transforming growth factor beta (TGF-β) signaling, is frequently inactivated in human cancer. Although the ubiquitin-proteasome pathway has been established as one mechanism of inactivating Smad4 in cancer, the specific ubiquitin E3 ligase for ubiquitination...

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Hlavní autoři: Liang, Min, Liang, Yao-Yun, Wrighton, Katharine, Ungermannova, Dana, Wang, Xiao-Ping, Brunicardi, F. Charles, Liu, Xuedong, Feng, Xin-Hua, Lin, Xia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC506984/
https://ncbi.nlm.nih.gov/pubmed/15314162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7524-7537.2004
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