Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCF(Skp2)

Smad4/DPC4, a common signal transducer in transforming growth factor beta (TGF-β) signaling, is frequently inactivated in human cancer. Although the ubiquitin-proteasome pathway has been established as one mechanism of inactivating Smad4 in cancer, the specific ubiquitin E3 ligase for ubiquitination...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Liang, Min, Liang, Yao-Yun, Wrighton, Katharine, Ungermannova, Dana, Wang, Xiao-Ping, Brunicardi, F. Charles, Liu, Xuedong, Feng, Xin-Hua, Lin, Xia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2004
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506984/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15314162/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.17.7524-7537.2004
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