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Ubiquitination and Proteolysis of Cancer-Derived Smad4 Mutants by SCF(Skp2)
Smad4/DPC4, a common signal transducer in transforming growth factor beta (TGF-β) signaling, is frequently inactivated in human cancer. Although the ubiquitin-proteasome pathway has been established as one mechanism of inactivating Smad4 in cancer, the specific ubiquitin E3 ligase for ubiquitination...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC506984/ https://ncbi.nlm.nih.gov/pubmed/15314162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7524-7537.2004 |
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