Immobilized Cobalt Affinity Chromatography Provides a Novel, Efficient Method for Herpes Simplex Virus Type 1 Gene Vector Purification

Herpes simplex virus type 1 (HSV-1) is a promising vector for gene therapy applications, particularly at peripheral nerves, the natural site of virus latency. Many gene vectors require large particle numbers for even early-phase clinical trials, emphasizing the need for high-yield, scalable manufact...

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Autores principales: Jiang, Canping, Wechuck, James B., Goins, William F., Krisky, David M., Wolfe, Darren, Ataai, Mohammad M., Glorioso, Joseph C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC506967/
https://ncbi.nlm.nih.gov/pubmed/15308696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.17.8994-9006.2004
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