CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer

Triple negative breast cancers exhibit very aggressive features and poor patient outcomes. These tumors are enriched in cancer stem cells and exhibit resistance to most treatments and chemotherapy. In this study, we found the cyclin-dependent kinase (CDK4) to act as a cancer stem cell regulator and...

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Udgivet i:Sci Rep
Main Authors: Dai, Meiou, Zhang, Chenjing, Ali, Ayad, Hong, Xinyuan, Tian, Jun, Lo, Chieh, Fils-Aimé, Nadège, Burgos, Sergio A., Ali, Suhad, Lebrun, Jean-Jacques
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069501/
https://ncbi.nlm.nih.gov/pubmed/27759034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35383
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