CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer

Triple negative breast cancers exhibit very aggressive features and poor patient outcomes. These tumors are enriched in cancer stem cells and exhibit resistance to most treatments and chemotherapy. In this study, we found the cyclin-dependent kinase (CDK4) to act as a cancer stem cell regulator and...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Dai, Meiou, Zhang, Chenjing, Ali, Ayad, Hong, Xinyuan, Tian, Jun, Lo, Chieh, Fils-Aimé, Nadège, Burgos, Sergio A., Ali, Suhad, Lebrun, Jean-Jacques
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069501/
https://ncbi.nlm.nih.gov/pubmed/27759034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35383
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