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Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes

Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hansen, Jan, Timmers, Silvie, Moonen-Kornips, Esther, Duez, Helene, Staels, Bart, Hesselink, Matthijs K. C., Schrauwen, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069469/
https://ncbi.nlm.nih.gov/pubmed/27756900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35047
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