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Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation

Activation of Aβ-fibers by is an intrinsic feature of spinal cord stimulation (SCS) pain therapy. Cannabinoid receptor type 1 (CB1) is important to neuronal plasticity and pain modulation, but its role in SCS-induced pain inhibition remains unclear. Here, we showed that CB1 receptors are expressed i...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Yang, Fei, Xu, Qian, Shu, Bin, Tiwari, Vinod, Shao-QiuHe, Vera-Portocarrero, Louis P., Dong, Xinzhong, Linderoth, Bengt, Raja, Srinivasa N., Wang, Yun, Guan, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069149/
https://ncbi.nlm.nih.gov/pubmed/27589093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000680
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