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Generation of a LacZ reporter transgenic mouse line for the stereological analysis of oligodendrocyte loss in galactosylceramidase deficiency
Krabbe’s disease is a leukodystrophy due to the deficiency of galactosyl-ceramidase and the accumulation of galactosyl-sphingosine (psychosine) in the nervous system. Psychosine is believed to cause central demyelination by killing oligodendrocytes. Quantitative analysis of this process is lacking....
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| Опубликовано в: : | J Neurosci Res |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5069144/ https://ncbi.nlm.nih.gov/pubmed/27426866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23839 |
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