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Lactate Metabolism is Associated with Mammalian Mitochondria

It is well established that lactate secreted by fermenting cells can be oxidized or used as a gluconeogenic substrate by other cells and tissues. Within the fermenting cell itself, however, it is generally assumed that lactate is produced to replenish NAD(+) and then is secreted. Here we explored th...

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Publicat a:Nat Chem Biol
Autors principals: Chen, Ying-Jr, Mahieu, Nathaniel G., Huang, Xiaojing, Singh, Manmilan, Crawford, Peter A, Johnson, Stephen L., Gross, Richard W., Schaefer, Jacob, Patti, Gary J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069139/
https://ncbi.nlm.nih.gov/pubmed/27618187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2172
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