A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice

H9N2 avian influenza virus (AIV) has an extended host range, but the molecular basis underlying H9N2 AIV transmission to mammals remains unclear. We isolated more than 900 H9N2 AIVs in our 3-year surveillance in live bird markets in China from 2009 to 2012. Thirty-seven representative isolates were...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Teng, Qiaoyang, Xu, Dawei, Shen, Weixia, Liu, Qinfang, Rong, Guangyu, Li, Xuesong, Yan, Liping, Yang, Jianmei, Chen, Hongjun, Yu, Hai, Ma, Wenjun, Li, Zejun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068531/
https://ncbi.nlm.nih.gov/pubmed/27558420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01141-16
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