A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice

H9N2 avian influenza virus (AIV) has an extended host range, but the molecular basis underlying H9N2 AIV transmission to mammals remains unclear. We isolated more than 900 H9N2 AIVs in our 3-year surveillance in live bird markets in China from 2009 to 2012. Thirty-seven representative isolates were...

Full description

Saved in:
Bibliographic Details
Published in:J Virol
Main Authors: Teng, Qiaoyang, Xu, Dawei, Shen, Weixia, Liu, Qinfang, Rong, Guangyu, Li, Xuesong, Yan, Liping, Yang, Jianmei, Chen, Hongjun, Yu, Hai, Ma, Wenjun, Li, Zejun
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068531/
https://ncbi.nlm.nih.gov/pubmed/27558420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01141-16
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items