Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4(+) T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

Despite the advent of combined antiretroviral therapy (cART), the persistence of viral reservoirs remains a major barrier to curing human immunodeficiency virus type 1 (HIV-1) infection. Recently, the shock and kill strategy, by which such reservoirs are eradicated following reactivation of latent H...

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Bibliographic Details
Published in:J Virol
Main Authors: Liu, Bingfeng, Zou, Fan, Lu, Lijuan, Chen, Cancan, He, Dalian, Zhang, Xu, Tang, Xiaoping, Liu, Chao, Li, Linghua, Zhang, Hui
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068523/
https://ncbi.nlm.nih.gov/pubmed/27535056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00852-16
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