Antimicrobial lipopeptide tridecaptin A(1) selectively binds to Gram-negative lipid II

Tridecaptin A(1) (TriA(1)) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA(1) exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force....

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Cochrane, Stephen A., Findlay, Brandon, Bakhtiary, Alireza, Acedo, Jeella Z., Rodriguez-Lopez, Eva M., Mercier, Pascal, Vederas, John C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068289/
https://ncbi.nlm.nih.gov/pubmed/27688760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608623113
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