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Antimicrobial lipopeptide tridecaptin A(1) selectively binds to Gram-negative lipid II
Tridecaptin A(1) (TriA(1)) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA(1) exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force....
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068289/ https://ncbi.nlm.nih.gov/pubmed/27688760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608623113 |
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