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Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics

The DNA strand exchange protein RAD51 facilitates the central step in homologous recombination, a process fundamentally important for accurate repair of damaged chromosomes, restart of collapsed replication forks, and telomere maintenance. The active form of RAD51 is a nucleoprotein filament that as...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Subramanyam, Shyamal, Ismail, Mohammed, Bhattacharya, Ipshita, Spies, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068273/
https://ncbi.nlm.nih.gov/pubmed/27671650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604807113
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