B7-H1 shapes T-cell–mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity

Molecular mechanisms that determine lesion localization or phenotype variation in multiple sclerosis are mostly unidentified. Although transmigration of activated encephalitogenic T cells across the blood–brain barrier (BBB) is a crucial step in the disease pathogenesis of CNS autoimmunity, the cons...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Klotz, Luisa, Kuzmanov, Ivan, Hucke, Stephanie, Gross, Catharina C., Posevitz, Vilmos, Dreykluft, Angela, Schulte-Mecklenbeck, Andreas, Janoschka, Claudia, Lindner, Maren, Herold, Martin, Schwab, Nicholas, Ludwig-Portugall, Isis, Kurts, Christian, Meuth, Sven G., Kuhlmann, Tanja, Wiendl, Heinz
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068266/
https://ncbi.nlm.nih.gov/pubmed/27671636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601350113
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