Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

Cell death and release of proinflammatory mediators contribute to mortality during sepsis. Specifically, caspase-11–dependent cell death contributes to pathology and decreases in survival time in sepsis models. Priming of the host cell, through TLR4 and interferon receptors, induces caspase-11 expre...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Napier, Brooke A., Brubaker, Sky W., Sweeney, Timothy E., Monette, Patrick, Rothmeier, Greggory H., Gertsvolf, Nina A., Puschnik, Andreas, Carette, Jan E., Khatri, Purvesh, Monack, Denise M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068231/
https://ncbi.nlm.nih.gov/pubmed/27697835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160027
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