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Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding

The molecular basis of the low-pH activation of the helicase encoded by the hepatitis C virus (HCV) was examined using either a full-length NS3 protein/NS4A cofactor complex or truncated NS3 proteins lacking the protease domain, which were isolated from three different viral genotypes. All proteins...

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Udgivet i:Nucleic Acids Res
Principais autores: Lam, Angela M. I., Rypma, Ryan S., Frick, David N.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC506820/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15289579/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh743
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