Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies

Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which encodes for the cardiac Na(+) channel. To date, vari...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Tse, Gary, Liu, Tong, Li, Ka H. C., Laxton, Victoria, Chan, Yin W. F., Keung, Wendy, Li, Ronald A., Yan, Bryan P.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067537/
https://ncbi.nlm.nih.gov/pubmed/27803673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00467
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