Identification of p38 MAPK and JNK as new targets for correction of Wilson disease‐causing ATP7B mutants

Wilson disease (WD) is an autosomal recessive disorder that is caused by the toxic accumulation of copper (Cu) in the liver. The ATP7B gene, which is mutated in WD, encodes a multitransmembrane domain adenosine triphosphatase that traffics from the trans‐Golgi network to the canalicular area of hepa...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Chesi, Giancarlo, Hegde, Ramanath N., Iacobacci, Simona, Concilli, Mafalda, Parashuraman, Seetharaman, Festa, Beatrice Paola, Polishchuk, Elena V., Di Tullio, Giuseppe, Carissimo, Annamaria, Montefusco, Sandro, Canetti, Diana, Monti, Maria, Amoresano, Angela, Pucci, Piero, van de Sluis, Bart, Lutsenko, Svetlana, Luini, Alberto, Polishchuk, Roman S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Steatohepatitis/Metabolic Liver Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066671/
https://ncbi.nlm.nih.gov/pubmed/26660341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28398
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