Polarized regulatory landscape and Wnt responsiveness underlie Hox activation in embryos

Sequential 3′-to-5′ activation of the Hox gene clusters in early embryos is a most fascinating issue in developmental biology. Neither the trigger nor the regulatory elements involved in the transcriptional initiation of the 3′-most Hox genes have been unraveled in any organism. We demonstrate that...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Neijts, Roel, Amin, Shilu, van Rooijen, Carina, Tan, Sander, Creyghton, Menno P., de Laat, Wouter, Deschamps, Jacqueline
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066237/
https://ncbi.nlm.nih.gov/pubmed/27633012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.285767.116
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