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Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode
Loss-of-function mutations in BSCL2 are responsible for Berardinelli-Seip congenital lipodystrophy, a rare disorder characterized by near absence of adipose tissue associated with insulin resistance. Seipin-deficient (Bscl2(−/−)) mice display an almost total loss of white adipose tissue (WAT) with r...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5066230/ https://ncbi.nlm.nih.gov/pubmed/27748422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35487 |
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