The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior

During tumor progression, alternative splicing gives rise to different Mena protein isoforms. We analyzed how Mena11a, an isoform enriched in epithelia and epithelial-like cells, affects Mena-dependent regulation of actin dynamics and cell behavior. While other Mena isoforms promote actin polymeriza...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Balsamo, Michele, Mondal, Chandrani, Carmona, Guillaume, McClain, Leslie M., Riquelme, Daisy N., Tadros, Jenny, Ma, Duan, Vasile, Eliza, Condeelis, John S., Lauffenburger, Douglas A., Gertler, Frank B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066228/
https://ncbi.nlm.nih.gov/pubmed/27748415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35298
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