A novel HSP90 inhibitor-drug conjugate to SN38 is highly effective in small cell lung cancer (SCLC)

PURPOSE: Small cell lung cancer (SCLC) is a highly aggressive disease representing 12-13% of total lung cancers, with median survival <2 years. No targeted therapies have proven effective in SCLC. While most patients respond initially to cytotoxic chemotherapies, resistance rapidly emerges, respo...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Gaponova, Anna V., Nikonova, Anna S., Deneka, Alexander, Kopp, Meghan C., Kudinov, Alexander E., Skobeleva, Natalia, Khazak, Vladimir, Ogawa, Luisa S., Cai, Kathy Q., Duncan, Kelly E., Duncan, James S., Egleston, Brian L., Proia, David A., Boumber, Yanis, Golemis, Erica A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065742/
https://ncbi.nlm.nih.gov/pubmed/27267850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-3068
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