In vivo Evaluation of Two Thiazolidin-4-one Derivatives in High Sucrose Diet Fed Pre-diabetic Mice and Their Modulatory Effect on AMPK, Akt and p38 MAP Kinase in L6 Cells

We had previously demonstrated the anti-diabetic potential and pancreatic protection of two thiazolidin-4-one derivatives containing nicotinamide moiety (NAT-1 and NAT-2) in STZ-induced diabetic mice. However, due to the limitations of the STZ model, we decided to undertake a detailed evaluation of...

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Pubblicato in:Front Pharmacol
Autori principali: Mudgal, Jayesh, Shetty, Priya, Reddy, Neetinkumar D., Akhila, H. S., Gourishetti, Karthik, Mathew, Geetha, Nayak, Pawan G., Kumar, Nitesh, Kishore, Anoop, Kutty, Nampurath G., Nandakumar, Krishnadas, Shenoy, Rekha R., Rao, Chamallamudi M., Joseph, Alex
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064669/
https://ncbi.nlm.nih.gov/pubmed/27790148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00381
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