Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

TRPV ion channels are directly activated by sensory stimuli and participate in thermo-, mechano- and chemo-sensation. They are also hypothesized to respond to endogenous agonists that would modulate sensory responses. Here, we show that the nicotinamide (NAM) form of vitamin B(3) is an agonist of a...

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Publicado no:Nat Commun
Main Authors: Upadhyay, Awani, Pisupati, Aditya, Jegla, Timothy, Crook, Matt, Mickolajczyk, Keith J., Shorey, Matthew, Rohan, Laura E., Billings, Katherine A., Rolls, Melissa M., Hancock, William O., Hanna-Rose, Wendy
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064019/
https://ncbi.nlm.nih.gov/pubmed/27731314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13135
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