SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores

Chromosome alignment is required for accurate chromosome segregation. Chromosome misalignment can result in genomic instability and tumorigenesis. Here, we show that NF-κB activating protein (NKAP) is critical for chromosome alignment through anchoring CENP-E to kinetochores. NKAP knockdown causes c...

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Vydáno v:Nat Commun
Hlavní autoři: Li, Teng, Chen, Liang, Cheng, Juanxian, Dai, Jiang, Huang, Yijiao, Zhang, Jian, Liu, Zhaoshan, Li, Ang, Li, Na, Wang, Hongxia, Yin, Xiaomin, He, Kun, Yu, Ming, Zhou, Tao, Zhang, Xuemin, Xia, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064014/
https://ncbi.nlm.nih.gov/pubmed/27694884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12969
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