iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy

Mesenchymal stem cells (MSCs) can donate mitochondria and rescue anthracycline-induced cardiomyocyte (CM) damage, although the underlying mechanisms remain elusive. We determined that the superior efficiency of mitochondrial transfer by human induced-pluripotent-stem-cell-derived MSCs (iPSC-MSCs) co...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Zhang, Yuelin, Yu, Zhendong, Jiang, Dan, Liang, Xiaoting, Liao, Songyan, Zhang, Zhao, Yue, Wensheng, Li, Xiang, Chiu, Sin-Ming, Chai, Yuet-Hung, Liang, Yingmin, Chow, Yenyen, Han, Shuo, Xu, Aimin, Tse, Hung-Fat, Lian, Qizhou
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063626/
https://ncbi.nlm.nih.gov/pubmed/27641650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.08.009
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