ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation

Huntington's disease (HD) is characterized by fatal motoric failures induced by loss of striatal medium spiny neurons. Neuronal cell death has been linked to impaired expression and axonal transport of the neurotrophin BDNF (brain-derived neurotrophic factor). By transplanting embryonic stem ce...

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發表在:Stem Cell Reports
Main Authors: Zimmermann, Tina, Remmers, Floortje, Lutz, Beat, Leschik, Julia
格式: Artigo
語言:Inglês
出版: Elsevier 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063570/
https://ncbi.nlm.nih.gov/pubmed/27693427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.08.018
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