Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

BACKGROUND: Radiation therapy is the most commonly used postsurgical treatment for primary malignant brain tumors. Consequently, investigating the efficacy of chemotherapeutics combined with radiation for treating malignant brain tumors is of high clinical relevance. In this study, we examined the c...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Hashizume, Rintaro, Zhang, Ali, Mueller, Sabine, Prados, Michael D., Lulla, Rishi R., Goldman, Stewart, Saratsis, Amanda M., Mazar, Andrew P., Stegh, Alexander H., Cheng, Shi-Yuan, Horbinski, Craig, Haas-Kogan, Daphne A., Sarkaria, Jann N., Waldman, Todd, James, C. David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2016
Aiheet:
Basic and Translational Investigation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063519/
https://ncbi.nlm.nih.gov/pubmed/27370397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now106
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