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Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies

Many transition metal complexes have unique physicochemical properties that can be efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double‐stranded DNA has been assumed to be the main binding target; however, recent studies have shown that nucleosomal DNA as well as...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Palermo, Giulia, Magistrato, Alessandra, Riedel, Tina, von Erlach, Thibaud, Davey, Curt A., Dyson, Paul J., Rothlisberger, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063137/
https://ncbi.nlm.nih.gov/pubmed/26634638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500478
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