Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease

Genome-wide association studies (GWAS) of chronic periodontitis (CP) defined by clinical criteria alone have had modest success to-date. Here, we refine the CP phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Offenbacher, Steven, Divaris, Kimon, Barros, Silvana P., Moss, Kevin L., Marchesan, Julie T., Morelli, Thiago, Zhang, Shaoping, Kim, Steven, Sun, Lu, Beck, James D., Laudes, Matthias, Munz, Matthias, Schaefer, Arne S., North, Kari E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062586/
https://ncbi.nlm.nih.gov/pubmed/26962152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw069
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