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Development of a one-pot assay for screening and identification of Mur pathway inhibitors in Mycobacterium tuberculosis

The cell wall of Mycobacterium tuberculosis (Mtb) consists of peptidoglycan, arabinogalactan and mycolic acids. The cytoplasmic steps in the peptidoglycan biosynthetic pathway, catalyzed by the Mur (A-F) enzymes, involve the synthesis of UDP-n-acetylmuramyl pentapeptide, a key precursor molecule req...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Eniyan, Kandasamy, Kumar, Anuradha, Rayasam, Geetha Vani, Perdih, Andrej, Bajpai, Urmi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062083/
https://ncbi.nlm.nih.gov/pubmed/27734910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35134
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