Prospective dose selection and acceleration of paliperidone palmitate 3‐month formulation development using a pharmacometric bridging strategy

AIMS: To prospectively select the dose of the paliperidone palmitate 3‐month (PP3M) formulation, using a pharmacometric bridging strategy based on the paliperidone palmitate 1‐month (PP1M) formulation previously approved for schizophrenia treatment. METHODS: Pharmacokinetic (PK) data from a 6‐month...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Samtani, Mahesh N., Nandy, Partha, Ravenstijn, Paulien, Remmerie, Bart, Vermeulen, An, Russu, Alberto, D'hoore, Peter, Baum, Ellen Z., Savitz, Adam, Gopal, Srihari, Hough, David
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Methods in Clinical Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061800/
https://ncbi.nlm.nih.gov/pubmed/27333588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13050
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