Suppressors of Superoxide-H(2)O(2) Production at Site I(Q) of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

Using high-throughput screening we identified small molecules that suppress superoxide and/or H(2)O(2) production during reverse electron transport through mitochondrial respiratory complex I (site I(Q)) without affecting oxidative phosphorylation (suppressors of site I(Q) electron leak, “S1QELs”)....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Brand, Martin D., Goncalves, Renata L.S., Orr, Adam L., Vargas, Leonardo, Gerencser, Akos A., Jensen, Martin Borch, Wang, Yves T., Melov, Simon, Turk, Carolina N., Matzen, Jason T., Dardov, Victoria J., Petrassi, H. Michael, Meeusen, Shelly L., Perevoshchikova, Irina V., Jasper, Heinrich, Brookes, Paul S., Ainscow, Edward K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061631/
https://ncbi.nlm.nih.gov/pubmed/27667666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.08.012
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados