Oxidation increases the strength of the methionine-aromatic interaction

Oxidation of methionine disrupts the structure and function of a range of proteins, but little is understood about the chemistry that underlies these perturbations. Using quantum mechanical calculations, we show that oxidation increases the strength of the methionine-aromatic interaction motif—a dri...

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Publicado no:Nat Chem Biol
Main Authors: Lewis, Andrew K., Dunleavy, Katie, Senkow, Tiffany L., Her, Cheng, Horn, Benjamin T., Jersett, Mark A., Mahling, Ryan, McCarthy, Megan R., Perell, Gabriella T., Valley, Christopher C., Karim, Christine B., Gao, Jiali, Pomerantz, William C. K., Thomas, David D., Cembran, Alessandro, Hinderliter, Anne, Sachs, Jonathan N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5060120/
https://ncbi.nlm.nih.gov/pubmed/27547920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2159
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