The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia

The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates phosphatidylinositol 3-kinase (PI3K)-AKT signaling and is often inactivated by mutations (including deletions) in a variety of cancer types, including T-cell acute lymphoblastic leukemia. Here we review mutation-associat...

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Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Mendes, Rui D., Canté-Barrett, Kirsten, Pieters, Rob, Meijerink, Jules P.P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2016
Ämnen:
Review Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5060017/
https://ncbi.nlm.nih.gov/pubmed/27582570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.146381
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