Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 pa...

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Publicat a:Nat Commun
Autors principals: Zhao, Ling-Hao, Liu, Xiao, Yan, He-Xin, Li, Wei-Yang, Zeng, Xi, Yang, Yuan, Zhao, Jie, Liu, Shi-Ping, Zhuang, Xue-Han, Lin, Chuan, Qin, Chen-Jie, Zhao, Yi, Pan, Ze-Ya, Huang, Gang, Liu, Hui, Zhang, Jin, Wang, Ruo-Yu, Yang, Yun, Wen, Wen, Lv, Gui-Shuai, Zhang, Hui-Lu, Wu, Han, Huang, Shuai, Wang, Ming-Da, Tang, Liang, Cao, Hong-Zhi, Wang, Ling, Lee, Tin-Lap, Jiang, Hui, Tan, Ye-Xiong, Yuan, Sheng-Xian, Hou, Guo-Jun, Tao, Qi-Fei, Xu, Qin-Guo, Zhang, Xiu-Qing, Wu, Meng-Chao, Xu, Xun, Wang, Jun, Yang, Huan-Ming, Zhou, Wei-Ping, Wang, Hong-Yang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059470/
https://ncbi.nlm.nih.gov/pubmed/27703150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12992
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