Novel Direct Assay for Acetyl-CoA:α-Glucosaminide N-Acetyltransferase Using BODIPY-Glucosamine as a Substrate

Heparan sulfate acetyl-CoA:α-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism. Inherited deficiency of HGSNAT in humans results in lysosomal storage of heparan sulfate and causes severe neurodegener...

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Detalhes bibliográficos
Publicado no:JIMD Rep
Main Authors: Choi, Yoo, Tuzikov, Alexander B., Ovchinnikova, Tatyana V., Bovin, Nicolai V., Pshezhetsky, Alexey V.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059212/
https://ncbi.nlm.nih.gov/pubmed/26493749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/8904_2015_501
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