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Na(+)/K(+)ATPase Regulates Sperm Capacitation Through a Mechanism Involving Kinases and Redistribution of Its Testis-Specific Isoform

Incubation of bovine sperm with ouabain, an endogenous cardiac glycoside that inhibits both the ubiquitous (ATP1A1) and testis-specific α4 (ATP1A4) isoforms of Na(+)/K(+)ATPase, induces tyrosine phosphorylation and capacitation. The objectives of this study were to investigate: (1) fertilizing abili...

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Detalhes bibliográficos
Publicado no:Mol Reprod Dev
Main Authors: NEWTON, LARISSA D., KRISHNAKUMAR, SULOCHANA, MENON, AJITKUMAR GOPINADHA, KASTELIC, JOHN P., VAN DER HOORN, FRANS A., THUNDATHIL, JACOB C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059152/
https://ncbi.nlm.nih.gov/pubmed/19834983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrd.21114
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