Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells

Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the antitumoral activity of Amitriptyline, a tricyclic antidepressant, in hepatoma cells. Amitriptyline-induced toxicity involved early mitophagy activation that subsequently switched to ap...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genes Cancer
Auteurs principaux: Villanueva-Paz, Marina, Cordero, Mario D., Pavón, Ana Delgado, Vega, Beatriz Castejón, Cotán, David, De la Mata, Mario, Oropesa-Ávila, Manuel, Alcocer-Gomez, Elizabet, de Lavera, Isabel, Garrido-Maraver, Juan, Carrascosa, José, Zaderenko, Ana Paula, Muntané, Jordi, de Miguel, Manuel, Sánchez-Alcázar, José Antonio
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059116/
https://ncbi.nlm.nih.gov/pubmed/27738496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/genesandcancer.114
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