N-acetylcysteine negatively regulates Notch3 and its malignant signaling

Notch3 receptor is expressed in a variety of cancers and the excised active intracellular domain (N3ICD) initiates its signaling cascade. N-acetylcysteine (NAC) as an antioxidant has been implicated in cancer prevention and therapy. In this study, we demonstrated a negative regulation of Notch3 by N...

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Publicado en:Oncotarget
Autores principales: Zhang, Xiong, Wang, Ya-Nan, Zhu, Juan-Juan, Liu, Xue-Xia, You, Hui, Gong, Mei-Ying, Zou, Ming, Cheng, Wen-Hsing, Zhu, Jian-Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058723/
https://ncbi.nlm.nih.gov/pubmed/27102435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8806
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