A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells

We recently reported that Fhit is in a molecular complex with annexin A4 (ANXA4); following to their binding, Fhit delocalizes ANXA4 from plasma membrane to cytosol in paclitaxel-resistant lung cancer cells, thus restoring their chemosensitivity to the drug. Here, we demonstrate that Fhit physically...

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Publicado en:Oncotarget
Autores principales: Gaudio, Eugenio, Paduano, Francesco, Ngankeu, Apollinaire, Ortuso, Francesco, Lovat, Francesca, Pinton, Sandra, D'Agostino, Sabrina, Zanesi, Nicola, Aqeilan, Rami I., Campiglia, Pietro, Novellino, Ettore, Alcaro, Stefano, Croce, Carlo M., Trapasso, Francesco
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058653/
https://ncbi.nlm.nih.gov/pubmed/27166255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9179
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