Safety of striatal infusion of siRNA in a transgenic Huntington's disease mouse model

BACKGROUND: The immune system In Huntington's disease (HD) is activated and may overreact to some therapies. RNA interference using siRNA lowers mutant huntingtin (mHTT) protein but could increase immune responses. OBJECTIVE: To examine the innate immune response following siRNA infusion into t...

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發表在:J Huntingtons Dis
Main Authors: Johnson, Emily, Chase, Kathryn, McGowan, Sarah, Mondo, Erica, Pfister, Edith, Mick, Eric, Friedline, Randall H., Kim, Jason K., Sapp, Ellen, DiFiglia, Marian, Aronin, Neil
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058343/
https://ncbi.nlm.nih.gov/pubmed/26444021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-150163
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