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Safety of striatal infusion of siRNA in a transgenic Huntington's disease mouse model
BACKGROUND: The immune system In Huntington's disease (HD) is activated and may overreact to some therapies. RNA interference using siRNA lowers mutant huntingtin (mHTT) protein but could increase immune responses. OBJECTIVE: To examine the innate immune response following siRNA infusion into t...
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| Publicado no: | J Huntingtons Dis |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5058343/ https://ncbi.nlm.nih.gov/pubmed/26444021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-150163 |
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