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Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals
BACKGROUND: Receptor occupancy (RO) assays measure drug target engagement, and are used as pharmacodynamic (PD) biomarkers. RO assays are commonly performed by flow cytometry and often require multiplexing for assessment of multiple PD biomarkers when specimen volumes are limited. We present multipl...
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| Publicat a: | Cytometry B Clin Cytom |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5057311/ https://ncbi.nlm.nih.gov/pubmed/26332491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.b.21319 |
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