GEF-H1 is necessary for neutrophil shear stress–induced migration during inflammation

Leukocyte crawling and transendothelial migration (TEM) are potentiated by shear stress caused by blood flow. The mechanism that couples shear stress to migration has not been fully elucidated. We found that mice lacking GEF-H1 (GEF-H1(−/−)), a RhoA-specific guanine nucleotide exchange factor (GEF),...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Fine, Noah, Dimitriou, Ioannis D., Rullo, Jacob, Sandí, María José, Petri, Björn, Haitsma, Jack, Ibrahim, Hisham, La Rose, Jose, Glogauer, Michael, Kubes, Paul, Cybulsky, Myron, Rottapel, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057286/
https://ncbi.nlm.nih.gov/pubmed/27738004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201603109
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