GEF-H1 is necessary for neutrophil shear stress–induced migration during inflammation

Leukocyte crawling and transendothelial migration (TEM) are potentiated by shear stress caused by blood flow. The mechanism that couples shear stress to migration has not been fully elucidated. We found that mice lacking GEF-H1 (GEF-H1(−/−)), a RhoA-specific guanine nucleotide exchange factor (GEF),...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Fine, Noah, Dimitriou, Ioannis D., Rullo, Jacob, Sandí, María José, Petri, Björn, Haitsma, Jack, Ibrahim, Hisham, La Rose, Jose, Glogauer, Michael, Kubes, Paul, Cybulsky, Myron, Rottapel, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057286/
https://ncbi.nlm.nih.gov/pubmed/27738004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201603109
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