Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.
In Saccharomyces cerevisiae cells harboring a GAL1 promoter-linked beta-galactosidase gene, the simultaneous expression of Escherichia coli DNA topoisomerase I and inactivation of yeast DNA topoisomerases I and II reduces the cellular level of beta-galactosidase to an undetectable level. Analysis of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50571/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1333610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.23.11461 |
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