Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments

No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) for gene silencing has been completed before. To assess the influence of experimental parameters like cell line, transfection technique, validation method, and type of control, we have to validate the...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Munkácsy, Gyöngyi, Sztupinszki, Zsófia, Herman, Péter, Bán, Bence, Pénzváltó, Zsófia, Szarvas, Nóra, Győrffy, Balázs
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056990/
https://ncbi.nlm.nih.gov/pubmed/27673562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.66
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