Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments

No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) for gene silencing has been completed before. To assess the influence of experimental parameters like cell line, transfection technique, validation method, and type of control, we have to validate the...

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Detalles Bibliográficos
Publicado en:Mol Ther Nucleic Acids
Main Authors: Munkácsy, Gyöngyi, Sztupinszki, Zsófia, Herman, Péter, Bán, Bence, Pénzváltó, Zsófia, Szarvas, Nóra, Győrffy, Balázs
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056990/
https://ncbi.nlm.nih.gov/pubmed/27673562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.66
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