Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8(+) T Cells

Polyomavirus BK (BKPyV) frequently reactivates in immunosuppressed renal transplant recipients (RTRs) and may lead to graft loss due to BKPyV-induced interstitial nephritis (BKVN). Little is known on the differentiation of CD8(+) T cells targeting BKPyV in RTRs. Here we investigated whether BKPyV-sp...

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Publicado no:PLoS Pathog
Main Authors: van Aalderen, Michiel C., Remmerswaal, Ester B. M., Heutinck, Kirstin M., ten Brinke, Anja, Feltkamp, Mariet C. W., van der Weerd, Neelke C., van der Pant, Karlijn A. M. I., Bemelman, Frederike J., van Lier, René A. W., ten Berge, Ineke J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056763/
https://ncbi.nlm.nih.gov/pubmed/27723787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005903
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