A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells

Phosphatase and tensin homolog (PTEN) gene is considered a tumor suppressor gene. However, PTEN mutations rarely occur in hepatocellular carcinoma (HCC), whereas heterozygosity of PTEN, resulting in reduced PTEN expression, has been observed in 32–44% of HCC patients. In the present study, we invest...

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Publicat a:Cell Cycle
Autors principals: Augello, Giuseppa, Puleio, Roberto, Emma, Maria Rita, Cusimano, Antonella, Loria, Guido R., McCubrey, James A., Montalto, Giuseppe, Cervello, Melchiorre
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
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Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056616/
https://ncbi.nlm.nih.gov/pubmed/26794644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1138183
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