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Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment

Group 1 metabotropic glutamate receptors (mGluR1/mGluR5) play an integral role in neurodevelopment and are implicated in psychiatric disorders, such as schizophrenia. mGluR1 and mGluR5 are expressed as homodimers, which is important for their functionality and pharmacology. We examined the protein e...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lum, Jeremy S., Fernandez, Francesca, Matosin, Natalie, Andrews, Jessica L., Huang, Xu-Feng, Ooi, Lezanne, Newell, Kelly A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056358/
https://ncbi.nlm.nih.gov/pubmed/27721389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34391
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