Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with a unique geographical distribution. The genomic abnormalities leading to NPC pathogenesis remain unclear. In total, 135 NPC tumors were examined to characterize the mutational landscape using whole-exome sequencing and targeted resequen...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zheng, Hong, Dai, Wei, Cheung, Arthur Kwok Leung, Ko, Josephine Mun Yee, Kan, Rebecca, Wong, Bonnie Wing Yan, Leong, Merrin Man Long, Deng, Mingdan, Kwok, Tommy Chin Tung, Chan, Jimmy Yu-Wai, Kwong, Dora Lai-Wan, Lee, Anne Wing-Mui, Ng, Wai Tong, Ngan, Roger Kai Cheong, Yau, Chun Chung, Tung, Stewart, Lee, Victor Ho-fun, Lam, Ka-On, Kwan, Chung Kong, Li, Wing Sum, Yau, Stephen, Chan, Kwok-Wah, Lung, Maria Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056105/
https://ncbi.nlm.nih.gov/pubmed/27647909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607606113
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