Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT

Myosin-1C (MYO1C) is a tumor suppressor candidate located in a region of recurrent losses distal to TP53. Myo1c can tightly and specifically bind to PIP2, the substrate of Phosphoinositide 3-kinase (PI3K), and to Rictor, suggesting a role for MYO1C in the PI3K pathway. This study was designed to exa...

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Udgivet i:PLoS One
Main Authors: Visuttijai, Kittichate, Pettersson, Jennifer, Mehrbani Azar, Yashar, van den Bout, Iman, Örndal, Charlotte, Marcickiewicz, Janusz, Nilsson, Staffan, Hörnquist, Michael, Olsson, Björn, Ejeskär, Katarina, Behboudi, Afrouz
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055341/
https://ncbi.nlm.nih.gov/pubmed/27716847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164063
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